The I-STEM Resource Network is an unprecedented partnership of public and private higher education institutions, K-12 schools, business, and government. Started as a collaboration among 18 institutions of higher education in 10 regions throughout Indiana, I-STEM includes committees comprised of educational content experts and practitioners who come together to design and employ programs to address STEM issues. I-STEM works to support K–12 teachers and leaders working to implement high academic standards towards STEM literacy for all students. It also provides Indiana education leaders with new knowledge about teaching and learning. The I-STEM vision is for Indiana to be a national leader in student academic achievement in STEM disciplines and improve the quality of the workforce.