I-STEM is pleased to have these partners join with us to advance STEM education in Indiana:
| Eli Lilly & Company | The Lilly Endowment |
| The Indiana Department of Education | BioCrossroads |
| The Indiana Department of Workforce Development |
Roche Diagnostics |
| The Indiana Commission for Higher Education |
NSWC Crane |
| Cummins | Rolls-Royce |
| Dow AgroSciences | Cook Medical |
| Interactive Intelligence | EcO Coalition |
| Indiana Chamber of Commerce | Indiana State University |
| Purdue University | Indiana University |
| Notre Dame University | Ball State University |
| Rose-Hulman Institute of Technology | Science Central |
| University of Southern Indiana | Girl Scouts |
| Indiana University-Purdue University Fort Wayne | The Indianapolis Zoo |
| Indiana University-Purdue University Indianapolis | MSD Warren Township |
| University of Indianapolis | 1st Maker Space |
| Ivy Tech Community College | Raytheon |
| Marian University | FIRST Robotics |
| Conner Prairie Historical Park | Indiana State Museum |
| The Children’s Museum of Indianapolis | Million Women Mentors |
| The Indiana Girls Collaborative Project | Indiana 4H |
| Boy Scouts Crossroads Council | IU Health |
| TechPoint Foundation for Youth | The STEM Connection |